Limits...
Herpes Encephalitis

Smirniotopoulos, M.D. JGSM - MedPix (2011)

View Article: MedPix Image - MedPix Topic

Affiliation: Uniformed Services University

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The herpes virus family, including herpes simplex virus (HSV) is a group of eight double-stranded DNA viruses that can establish latency and lie dormant within living human cells (e.g. neurons)... PMID: 18657720 HSV 1 may also reside in the geniculate ganglia of the facial nerve, and may cause recurrent Bell's palsy (facial paralysis)... The incidence HSE (herpes simplex encephalitis) is estimated at roughly one case per million per year... Herpes labialis (HSV1) is the most common cause of viral encephalitis - representing 90% of herpes simplex encephalitis; and, most of these patients are immunocompetent adults... Imaging cannot rule-out HSV encephalitis Depending on the stage and course of the disease, even MR imaging can be "normal" in up to 1/3 of patients with HSE... The WM and and basal ganglia are less commonly affected in adults with HSV1 -while brainstem lesons are not atypical... PMID:15885053 Some sources suggest 20 mg/kg in very young children... NOTE: Any delay in Tx is associated with worse outcome... Acyclovir may be started while PCR is pending... Acyclovir is a specific for HSV infected cells, tolerated well and high safety margin... PMID: 14978145 Corticosteroids may improve prognosis... Relapse is possible.

No MeSH data available.


Herpes simplex encephalitis usually affects the cortical gray matter, especially early in the disease.  Temporal lobe and insular cortex are usually first - with abnormal signal intensity (bright on FLAIR and T2W), cortical thickening (sulcal effacement), and variable enhancement.  Similar changes occur in the cingulate gyrus in up to 2/3 of patients.The inferior frontal gyri may be affected next.  Since vascular/ischemic lesions also affect the cortex, a non-vascular pattern of involvement (e.g. bilateral insula or insula plus cingulate) can be very helpful.  Involvement of the basal ganglia gray matter is uncommon and/or late in the course of HSV encephalitis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=MPX2639&req=5

MPX2639_synpic55535: Herpes simplex encephalitis usually affects the cortical gray matter, especially early in the disease. Temporal lobe and insular cortex are usually first - with abnormal signal intensity (bright on FLAIR and T2W), cortical thickening (sulcal effacement), and variable enhancement. Similar changes occur in the cingulate gyrus in up to 2/3 of patients.The inferior frontal gyri may be affected next. Since vascular/ischemic lesions also affect the cortex, a non-vascular pattern of involvement (e.g. bilateral insula or insula plus cingulate) can be very helpful. Involvement of the basal ganglia gray matter is uncommon and/or late in the course of HSV encephalitis.


Herpes Encephalitis

Smirniotopoulos, M.D. JGSM - MedPix (2011)

Herpes simplex encephalitis usually affects the cortical gray matter, especially early in the disease.  Temporal lobe and insular cortex are usually first - with abnormal signal intensity (bright on FLAIR and T2W), cortical thickening (sulcal effacement), and variable enhancement.  Similar changes occur in the cingulate gyrus in up to 2/3 of patients.The inferior frontal gyri may be affected next.  Since vascular/ischemic lesions also affect the cortex, a non-vascular pattern of involvement (e.g. bilateral insula or insula plus cingulate) can be very helpful.  Involvement of the basal ganglia gray matter is uncommon and/or late in the course of HSV encephalitis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2639&req=5

MPX2639_synpic55535: Herpes simplex encephalitis usually affects the cortical gray matter, especially early in the disease. Temporal lobe and insular cortex are usually first - with abnormal signal intensity (bright on FLAIR and T2W), cortical thickening (sulcal effacement), and variable enhancement. Similar changes occur in the cingulate gyrus in up to 2/3 of patients.The inferior frontal gyri may be affected next. Since vascular/ischemic lesions also affect the cortex, a non-vascular pattern of involvement (e.g. bilateral insula or insula plus cingulate) can be very helpful. Involvement of the basal ganglia gray matter is uncommon and/or late in the course of HSV encephalitis.

View Article: MedPix Image - MedPix Topic

Affiliation: Uniformed Services University

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The herpes virus family, including herpes simplex virus (HSV) is a group of eight double-stranded DNA viruses that can establish latency and lie dormant within living human cells (e.g. neurons)... PMID: 18657720 HSV 1 may also reside in the geniculate ganglia of the facial nerve, and may cause recurrent Bell's palsy (facial paralysis)... The incidence HSE (herpes simplex encephalitis) is estimated at roughly one case per million per year... Herpes labialis (HSV1) is the most common cause of viral encephalitis - representing 90% of herpes simplex encephalitis; and, most of these patients are immunocompetent adults... Imaging cannot rule-out HSV encephalitis Depending on the stage and course of the disease, even MR imaging can be "normal" in up to 1/3 of patients with HSE... The WM and and basal ganglia are less commonly affected in adults with HSV1 -while brainstem lesons are not atypical... PMID:15885053 Some sources suggest 20 mg/kg in very young children... NOTE: Any delay in Tx is associated with worse outcome... Acyclovir may be started while PCR is pending... Acyclovir is a specific for HSV infected cells, tolerated well and high safety margin... PMID: 14978145 Corticosteroids may improve prognosis... Relapse is possible.

No MeSH data available.