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Sickle Cell Anemia

Smirniotopoulos, M.D. JGSM - MedPix (2000)

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Affiliation: Uniformed Services University

ABSTRACT

Sickle cell anemia (SCA) is an inherited hemogloblinopathy. Pts who are homozyogous have complications related to both the anemia and to repeated thrombotic vaso-occlusive episodes and hemolysis. Modern treatment has made a significant improvement in prognosis. In the early '70's, mean age at death was around 14 years old. In 1994 a study of almost 4k pts showed survival into the 40's for SCA, and twenty years longer for HbSC disease. Organ failures due to vaso-occlusion includes spleen ("auto-splenectomy"), kidney, lung, and brain. Treatment is aimed at minimizing both the frequency and the severity of the vaso-occlusive episodes of "sickle cell crisis". Extramedullary hematopoiesis Bone Changes Treatment of SSA: http://www.fda.gov/fdac/features/496_sick.html <hr> General Websites about SCD: http://sicklecelldisease.org/ http://www.yourgenesyourhealth.org/ygyh/mason/ygyh.html?syndrome=sickle http://www.cancer.mgh.harvard.edu/medOnc/sickle.htm http://www.ncbi.nlm.nih.gov/disease/sickle.html http://www.familyvillage.wisc.edu/lib_scd.htm More About SCD: http://rad.usuhs.mil/sickle/index.html What causes the hemoglobinopathy: http://www.emory.edu/PEDS/SICKLE/tutorial/Sickle%20Cell/sld001.htm

No MeSH data available.


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Sickle Cell Anemia

Smirniotopoulos, M.D. JGSM - MedPix (2000)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2616&req=5

View Article: MedPix Image - MedPix Topic

Affiliation: Uniformed Services University

ABSTRACT

Sickle cell anemia (SCA) is an inherited hemogloblinopathy. Pts who are homozyogous have complications related to both the anemia and to repeated thrombotic vaso-occlusive episodes and hemolysis. Modern treatment has made a significant improvement in prognosis. In the early '70's, mean age at death was around 14 years old. In 1994 a study of almost 4k pts showed survival into the 40's for SCA, and twenty years longer for HbSC disease. Organ failures due to vaso-occlusion includes spleen ("auto-splenectomy"), kidney, lung, and brain. Treatment is aimed at minimizing both the frequency and the severity of the vaso-occlusive episodes of "sickle cell crisis". Extramedullary hematopoiesis Bone Changes Treatment of SSA: http://www.fda.gov/fdac/features/496_sick.html <hr> General Websites about SCD: http://sicklecelldisease.org/ http://www.yourgenesyourhealth.org/ygyh/mason/ygyh.html?syndrome=sickle http://www.cancer.mgh.harvard.edu/medOnc/sickle.htm http://www.ncbi.nlm.nih.gov/disease/sickle.html http://www.familyvillage.wisc.edu/lib_scd.htm More About SCD: http://rad.usuhs.mil/sickle/index.html What causes the hemoglobinopathy: http://www.emory.edu/PEDS/SICKLE/tutorial/Sickle%20Cell/sld001.htm

No MeSH data available.