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Sparsely granulated growth hormone adenoma

USU Teaching File MUTF - MedPix

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Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Sparsely granulated growth hormone adenoma

History: This 50 year old woman had a several year history of enlarging hands and decreased visual acuity in her right eye.

Findings: Fig 1. Coronal CT showing the intrasellar tumor with suprasellar extension. Fig 2. Intraoperative smear prepared from the neoplasm showing sparsely granulated cytoplasm. Also note the occasional intracytoplasmic eosinophilic fibrous bodies, best seen in the very center of the picture. Fig 3. Histological section of the resected neoplasm showing the relatively uniform, sparsely granulated cells. Fig 4. Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.

Ddx: Sella and suprasellar mass: <li>pituitary adenoma <li>pituitary carcinoma or metastasis <li>craniopharyngioma

Exam: She was noted to have coarse facial features with prognathism, skin thickening and very large hands. Visual field examination disclosed a right nasal quadrantanopsia. The neurological examination was otherwise normal. Endocrine studies revealed an elevated baseline growth hormone level and normal prolactin.

No MeSH data available.


Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.
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MPX2460_synpic17269: Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.


Sparsely granulated growth hormone adenoma

USU Teaching File MUTF - MedPix

Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2460&req=5

MPX2460_synpic17269: Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Sparsely granulated growth hormone adenoma

History: This 50 year old woman had a several year history of enlarging hands and decreased visual acuity in her right eye.

Findings: Fig 1. Coronal CT showing the intrasellar tumor with suprasellar extension. Fig 2. Intraoperative smear prepared from the neoplasm showing sparsely granulated cytoplasm. Also note the occasional intracytoplasmic eosinophilic fibrous bodies, best seen in the very center of the picture. Fig 3. Histological section of the resected neoplasm showing the relatively uniform, sparsely granulated cells. Fig 4. Electron micrograph showing a typical intracytoplasmic body, characteristic of the sparsely granulated growth hormone secreting adenoma.

Ddx: Sella and suprasellar mass: <li>pituitary adenoma <li>pituitary carcinoma or metastasis <li>craniopharyngioma

Exam: She was noted to have coarse facial features with prognathism, skin thickening and very large hands. Visual field examination disclosed a right nasal quadrantanopsia. The neurological examination was otherwise normal. Endocrine studies revealed an elevated baseline growth hormone level and normal prolactin.

No MeSH data available.