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PANK 2 (Hallervorden-Spatz) PKAN (Pantothenate Kinase Associated Neurodegeneration)

Smirniotopoulos, M.D. JGSM - MedPix (2011)

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: PANK 2 (Hallervorden-Spatz) PKAN (Pantothenate Kinase Associated Neurodegeneration)

History: 5 y.o. girl with a history of gait problems presents with progressive dystonia and dysarthria, mild rigidity, and choreoathetosis. No Hx of seizures, infection, etc.

Findings: • Abnormal T2 hypointensity in the globus pallidus • Abnormal T2 hyperintensity in the center creating an "eye of the tiger" sign appearance

Ddx: • NBIA 1 - PKAN ("Hallervorden-Spatz" w/PANK2) • NBIA 1 - PKAN ("Hallervorden-Spatz" w/o PANK2) • NBIA 2 - Ferritin light-chain disease • INAD- infantile neuroaxonal dystrophy • Aceruloplasminemia

Dxhow: Clinical and Imaging findings

Exam: Neurologic exam shows spasticity, very brisk reflexes, and up-going toes. An MRI examination of the brain was ordered, to include a T2* image sequence.

No MeSH data available.


Classic 'eye of the tiger' appearance of PANK: hypointensity of the globus pallidus from iron deposition, with a medial hyper intensity. PMID: 16775270 PMID: 12510040
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MPX2399_synpic55890: Classic 'eye of the tiger' appearance of PANK: hypointensity of the globus pallidus from iron deposition, with a medial hyper intensity. PMID: 16775270 PMID: 12510040


PANK 2 (Hallervorden-Spatz) PKAN (Pantothenate Kinase Associated Neurodegeneration)

Smirniotopoulos, M.D. JGSM - MedPix (2011)

Classic 'eye of the tiger' appearance of PANK: hypointensity of the globus pallidus from iron deposition, with a medial hyper intensity. PMID: 16775270 PMID: 12510040
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2399&req=5

MPX2399_synpic55890: Classic 'eye of the tiger' appearance of PANK: hypointensity of the globus pallidus from iron deposition, with a medial hyper intensity. PMID: 16775270 PMID: 12510040

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: PANK 2 (Hallervorden-Spatz) PKAN (Pantothenate Kinase Associated Neurodegeneration)

History: 5 y.o. girl with a history of gait problems presents with progressive dystonia and dysarthria, mild rigidity, and choreoathetosis. No Hx of seizures, infection, etc.

Findings: • Abnormal T2 hypointensity in the globus pallidus • Abnormal T2 hyperintensity in the center creating an "eye of the tiger" sign appearance

Ddx: • NBIA 1 - PKAN ("Hallervorden-Spatz" w/PANK2) • NBIA 1 - PKAN ("Hallervorden-Spatz" w/o PANK2) • NBIA 2 - Ferritin light-chain disease • INAD- infantile neuroaxonal dystrophy • Aceruloplasminemia

Dxhow: Clinical and Imaging findings

Exam: Neurologic exam shows spasticity, very brisk reflexes, and up-going toes. An MRI examination of the brain was ordered, to include a T2* image sequence.

No MeSH data available.