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Spongioform Encephalopathy, Presumed variant Creutzfeldt-Jacob Disease

Thompson DT - MedPix

View Article: MedPix Image - MedPix Case

Affiliation: Brooke Army Medical Center

ABSTRACT

Diagnosis: Spongioform Encephalopathy, Presumed variant Creutzfeldt-Jacob Disease

History: 25 Y/O with new onset progrssive dementia, myclonus, EEG abnormalities, history of eating raw sheep's brain approximately 2 years ago.

Findings: Brain MRI scans approximately 6 months apart show progressive diffuse cortical atrophy, T2/FLAIR and Diffusion increased signal within the Basal Ganglia. Mild increased diffusion signal is seen in the posterior Thalamus (Pulvinar) Correspoding relatively decreased ADC map basal ganglia signal. MR Spectroscopy demonstrated a decrease in NAA peak.

Ddx: Cruetzfeldt-Jacob Disease Variant Creutzfeldt-Jacob Disease Other transmissible spongioform encephalopathies Diffuse ischemic insult Less likely: Methanol - putamen Carbon Monoxide - globus pallidus Deposition of iron or copper Neoplastic infiltration—particularly of lymphoma or glioma.

Dxhow: Frontal Lobe Biopsy

Exam: Left frontal lobe biopsy: Spongioform encephalopathy consistent with Creutzfeldt-Jacob disease.

No MeSH data available.


Diffusion weighted and corresponding ADC map image shows increased diffusion signal within caudate and putamen with decreased ADC map signal.
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MPX2236_synpic18696: Diffusion weighted and corresponding ADC map image shows increased diffusion signal within caudate and putamen with decreased ADC map signal.


Spongioform Encephalopathy, Presumed variant Creutzfeldt-Jacob Disease

Thompson DT - MedPix

Diffusion weighted and corresponding ADC map image shows increased diffusion signal within caudate and putamen with decreased ADC map signal.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX2236&req=5

MPX2236_synpic18696: Diffusion weighted and corresponding ADC map image shows increased diffusion signal within caudate and putamen with decreased ADC map signal.

View Article: MedPix Image - MedPix Case

Affiliation: Brooke Army Medical Center

ABSTRACT

Diagnosis: Spongioform Encephalopathy, Presumed variant Creutzfeldt-Jacob Disease

History: 25 Y/O with new onset progrssive dementia, myclonus, EEG abnormalities, history of eating raw sheep's brain approximately 2 years ago.

Findings: Brain MRI scans approximately 6 months apart show progressive diffuse cortical atrophy, T2/FLAIR and Diffusion increased signal within the Basal Ganglia. Mild increased diffusion signal is seen in the posterior Thalamus (Pulvinar) Correspoding relatively decreased ADC map basal ganglia signal. MR Spectroscopy demonstrated a decrease in NAA peak.

Ddx: Cruetzfeldt-Jacob Disease Variant Creutzfeldt-Jacob Disease Other transmissible spongioform encephalopathies Diffuse ischemic insult Less likely: Methanol - putamen Carbon Monoxide - globus pallidus Deposition of iron or copper Neoplastic infiltration—particularly of lymphoma or glioma.

Dxhow: Frontal Lobe Biopsy

Exam: Left frontal lobe biopsy: Spongioform encephalopathy consistent with Creutzfeldt-Jacob disease.

No MeSH data available.