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Medulloblastoma

Patterson RAP - MedPix (2007)

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Medulloblastoma

History: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

Findings: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

Exam: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

No MeSH data available.


Medulloblastoma
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MPX1819_synpic35511: Medulloblastoma


Medulloblastoma

Patterson RAP - MedPix (2007)

Medulloblastoma
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX1819&req=5

MPX1819_synpic35511: Medulloblastoma

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Medulloblastoma

History: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

Findings: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

Exam: Neoplasm Name: Medulloblastoma Synonyms: PNET (primitive neuroectodermal tumor), Central neuroblastoma Cell of Origin: Cell of origin is not clear. Several choices have been offered: 1) 'medulloblasts' 2) external granular cells 3) subependymal matrix cells 4) more than one cell of origin WHO Grade(s): WHO 4 Genetics and Associations: Demographics (Age, Sex, Incidence): Peak age is 7, 70% <16 (30%>15), most adults <40 65% Male (~2:1 M:F) Incidence - 0.5/100k in CHILDREN (<15 yo) Common Locations: Posterior fossa, usually midline Gross Appearance: Varies from soft to firm, some are well defined, may be hemorrhagic Radiology: Relatively homogeneous, may be uniformly hyperdense on non-contrast CT. MR signal similar to gray-matter, most not bright on T2W MR Histology: Densely cellular, hyperchromatic "carrot-shaped" nuclei, high nuclear to cytoplasm ratio, neuroblastic rosettes Special Stains: Prognosis and Treatment: Survival up to 85% at five years with combined radiation and chemotherapy [Magnani C, Pastore G: Survival of childhood cancer patients in Italy,1978-1989. ITACARE Working Group.Tumori 1997 Jan-Feb;83(1):426-89. Up to 100% in pts. w/o CSF spread (Bourne 1992 J Neurooncol) ======================================= See also:

No MeSH data available.