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Creutzfeldt-Jakob Disease

shaffer BMS - MedPix (2005)

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Creutzfeldt-Jakob Disease

History: 63 y/o male with history of NHL, and three weeks of decreasing visual acuity, gait ataxia, and poor coordination of left arm, that is worse in AM and improving during the course of day. New onset of personality changes and mood lability.

Findings: DWI Abnormalities in right occipital lobe/post temporal cortex w/o corresponding T2 changes. PET: abnormal hypometabolism R cerebrum and R cerebellum.

Ddx: Alzheimer disease, frontal and temporal dementia, HIV and HSV encephalitis, hydrocephalus, metabolic disorders, multi-infarct dementia, diffuse Lewey body disease, Hashimoto encephalopathy.

Dxhow: Brain Biopsy

Exam: Alert and Oriented X 3. Left homonymous hemianopsia with macular sparing, horizontal and vertical nystagmus, Normal DTRs bilat, severe upper extremity dysmetria on right, abnormal Romberg. Unable to do tandem gait, and bumps into objects on left. LP: Positive 14-3-3 protein, increased protein, RBCs, and polysegs. Elevated AST/ALT. Elevated thyroid auto-antibodies

No MeSH data available.


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Creutzfeldt-Jakob Disease

shaffer BMS - MedPix (2005)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX1788&req=5

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Creutzfeldt-Jakob Disease

History: 63 y/o male with history of NHL, and three weeks of decreasing visual acuity, gait ataxia, and poor coordination of left arm, that is worse in AM and improving during the course of day. New onset of personality changes and mood lability.

Findings: DWI Abnormalities in right occipital lobe/post temporal cortex w/o corresponding T2 changes. PET: abnormal hypometabolism R cerebrum and R cerebellum.

Ddx: Alzheimer disease, frontal and temporal dementia, HIV and HSV encephalitis, hydrocephalus, metabolic disorders, multi-infarct dementia, diffuse Lewey body disease, Hashimoto encephalopathy.

Dxhow: Brain Biopsy

Exam: Alert and Oriented X 3. Left homonymous hemianopsia with macular sparing, horizontal and vertical nystagmus, Normal DTRs bilat, severe upper extremity dysmetria on right, abnormal Romberg. Unable to do tandem gait, and bumps into objects on left. LP: Positive 14-3-3 protein, increased protein, RBCs, and polysegs. Elevated AST/ALT. Elevated thyroid auto-antibodies

No MeSH data available.