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Low grade myxofibrosarcoma

Nickens CMN - MedPix (2008)

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Low grade myxofibrosarcoma

History: This patient is a 76 year-old man with a past medical history significant for high grade malignant fibrous histiocytoma (MFH). He presented with multiple gradually enlarging painful nodules in the left leg. These lesions are located diffusely on the left lower leg and have been slowly enlarging as well as increasing in number over the past few months. Aside from these lesions, the patient has no complaints and is otherwise feeling healthy. Twice in the past three years the patient has been treated with wide excisions and radiation therapy for primary and recurrent high grade MFH. These tumors also presented as slow growing tender erythematous nodules and were located in the left proximal thigh, left proximal medial leg, and left distal medial leg.

Findings: A punch biopsy specimen from nodules on the left proximal medial leg and left distal posterior leg demonstrated spindled cells with hyperchromatic irregular nuclei and variable pleomorphism. They were isolated to the dermis and subcutaneous tissue, with a multinodular growth pattern and a prominent myxoid stroma. Scattered multinucleated cells were also present as were perivascular condensation of the tumor cells without vascular invasion. Perineural invasion was also present.

Exam: The patient is a well appearing, alert, oriented, afebrile, pleasant male in no acute distress. His left leg is modeled and edematous with two well healed skin grafts at the proximal medial and distal medial aspects. There are numerous skin to erythematous colored nodules on all aspects of the left lower leg. The nodules are 1-4 cm in diameter and tender to palpation. Initially, no labs were taken.

No MeSH data available.


A patient with low grade myxofibrosarcoma.
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MPX1623_synpic36861: A patient with low grade myxofibrosarcoma.


Low grade myxofibrosarcoma

Nickens CMN - MedPix (2008)

A patient with low grade myxofibrosarcoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX1623&req=5

MPX1623_synpic36861: A patient with low grade myxofibrosarcoma.

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Low grade myxofibrosarcoma

History: This patient is a 76 year-old man with a past medical history significant for high grade malignant fibrous histiocytoma (MFH). He presented with multiple gradually enlarging painful nodules in the left leg. These lesions are located diffusely on the left lower leg and have been slowly enlarging as well as increasing in number over the past few months. Aside from these lesions, the patient has no complaints and is otherwise feeling healthy. Twice in the past three years the patient has been treated with wide excisions and radiation therapy for primary and recurrent high grade MFH. These tumors also presented as slow growing tender erythematous nodules and were located in the left proximal thigh, left proximal medial leg, and left distal medial leg.

Findings: A punch biopsy specimen from nodules on the left proximal medial leg and left distal posterior leg demonstrated spindled cells with hyperchromatic irregular nuclei and variable pleomorphism. They were isolated to the dermis and subcutaneous tissue, with a multinodular growth pattern and a prominent myxoid stroma. Scattered multinucleated cells were also present as were perivascular condensation of the tumor cells without vascular invasion. Perineural invasion was also present.

Exam: The patient is a well appearing, alert, oriented, afebrile, pleasant male in no acute distress. His left leg is modeled and edematous with two well healed skin grafts at the proximal medial and distal medial aspects. There are numerous skin to erythematous colored nodules on all aspects of the left lower leg. The nodules are 1-4 cm in diameter and tender to palpation. Initially, no labs were taken.

No MeSH data available.