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Lhermitte Duclos disease, Cowden disease

USU Teaching File MUTF - MedPix

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Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Lhermitte Duclos disease, Cowden disease

History: This 56 year old woman had breast carcinoma for which she had bilateral mastectomies six years apart. She also had a thyroidectomy in her twenties. Six years after the second mastectomy, she developed gait unsteadiness that progressed to the point that she was unable to walk.

Findings: Fig 1. Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia. Fig 2. Axial T2 weighted MRI also showing the same coarse striations resulting from abnormally thick cerebellar folia. Fig 3. Gross appearance of a portion of the surgical specimen showing the coarse widened folia. Fig 4. Low magnification histological section showing subpial of myelinated fibers overlying a band of large neurons that replace the Purkinje cells and outer portion of the internal granular cell layer. Fig 5. Higher magnification of the abnormal large neurons.

Ddx: Cerebellar mass <li>Astrocytoma <li>Medulloblastoma (usually < 35 yo) <li>Cerebellar infarction <li>Lhermitte Duclos

No MeSH data available.


Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia.
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MPX1185_synpic17343: Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia.


Lhermitte Duclos disease, Cowden disease

USU Teaching File MUTF - MedPix

Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=MPX1185&req=5

MPX1185_synpic17343: Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia.

View Article: MedPix Image - MedPix Case

Affiliation: Uniformed Services University

ABSTRACT

Diagnosis: Lhermitte Duclos disease, Cowden disease

History: This 56 year old woman had breast carcinoma for which she had bilateral mastectomies six years apart. She also had a thyroidectomy in her twenties. Six years after the second mastectomy, she developed gait unsteadiness that progressed to the point that she was unable to walk.

Findings: Fig 1. Axial T1 weighted MRI shows coarse striations resulting from irregular, abnormally thickened cerebellar folia. Fig 2. Axial T2 weighted MRI also showing the same coarse striations resulting from abnormally thick cerebellar folia. Fig 3. Gross appearance of a portion of the surgical specimen showing the coarse widened folia. Fig 4. Low magnification histological section showing subpial of myelinated fibers overlying a band of large neurons that replace the Purkinje cells and outer portion of the internal granular cell layer. Fig 5. Higher magnification of the abnormal large neurons.

Ddx: Cerebellar mass <li>Astrocytoma <li>Medulloblastoma (usually < 35 yo) <li>Cerebellar infarction <li>Lhermitte Duclos

No MeSH data available.