Bottom Line: But even at 25 days normal crypt structures were still evident.They were no longer seen in explants examined after this time however and, indeed, there appeared to be no difference in the morphology and survival of control and DMH-treated mucosae.It is possible...

Bottom Line: Four sublines CMT167, 170, 175 and 181 with increased metastatic ability were selected, as described in the accompanying paper (Layton & Franks, 1984).No ultrastructural differences were found that might correlate with metastatic behaviour in vivo.Metastases,...

Bottom Line: Standard (UICC) crocidolite was subjected to ball milling to reduce the length of the fibre.Previous in vitro work on the same materials had suggested that biological activity was related to fibres greater than 6.5 microns in length and that the material milled...

Bottom Line: Not Available.

Bottom Line: These latter carcinomas were found in older patients (mean age 78 years vs 66 years).These results suggest that, on the proximal side, the stem cells were more often engaged in a differentiation process involving the expression of M antigens than were those...

Bottom Line: In 2 cases (1: NS, 1: LD) HD cells expressed clear, positive reactions with B1 although in neither of these cases nor in any other instance, was surface Ig expressed on the HD cell surface.On the basis of these findings, no lineage specificity can confidently...

Bottom Line: Not Available.

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Bottom Line: The role of the pancreaticotrophic hormone cholecystokinin (CCK) in modifying the pancreatic response to carcinogen has been examined in the hamster-nitrosamine pancreatic cancer model.Exogenous CCK, 30 IDU kg-1, stimulated a maximal pancreatic secretory response...

Bottom Line: Interobserver variation in grading was not improved by estimating proportions of differing grades in multiple samples from individual tumours.Non-diploid tumours were not of more advanced stage or poorer histological grade than diploid tumours.Since ploidy...