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Extraskeletal osteosarcoma of the thorax in a goat: case report

Braun U, Schwarzwald CC, Forster E, Becker-Birck M, Borel N, Ohlerth S - BMC Vet. Res. (2011)

Bottom Line: Ultrasonographic examination of the thorax revealed a precardial mass, measuring 16.4 by 11.4 by 14.2 cm.Computed tomographic examination showed dorsocaudal displacement of the trachea, heart and lungs to the right.A definitive diagnosis was based on histological examination of the mass.

Affiliation: Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. ubraun@vetclinics.uzh.ch

ABSTRACT

Background: This report describes the results of clinical, ultrasonographic and computed tomographic examination of a 16-year-old goat with extraskeletal osteosarcoma of the thorax.

Case presentation: The lead clinical signs were abnormal condition and demeanour, fever, tachycardia, tachypnoea, dyspnoea and dilated jugular veins. Ultrasonographic examination of the thorax revealed a precardial mass, measuring 16.4 by 11.4 by 14.2 cm. Computed tomographic examination showed dorsocaudal displacement of the trachea, heart and lungs to the right. A tentative diagnosis of mediastinal or pleural neoplasia was made, and the goat was euthanased and necropsied. A definitive diagnosis was based on histological examination of the mass.

Conclusions: To our knowledge, this case report is the first description of extraskeletal osteosarcoma of the thorax in goats and serves to broaden the diagnostic spectrum of thoracic diseases in this species. Extraskeletal osteosarcoma should be part of the differential diagnosis in goats with thoracic tumours.

Gross pathological findings. Gross pathological findings in a miniature goat with thoracic osteosarcoma. 1 Precardial mass, 2 Lung, 3 Heart.
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Figure 3: Gross pathological findings. Gross pathological findings in a miniature goat with thoracic osteosarcoma. 1 Precardial mass, 2 Lung, 3 Heart.

Mentions: Because the prognosis was grave, the goat was euthanased and a post-mortem examination was carried out. Examination of the thorax revealed a large firm white oval mass cranial to the heart (Figure 3). The mass displaced the heart to the right side of the thorax and resulted in compression of the heart, trachea and lungs. The cut surface of the mass had cystic lesions and a central area of necrosis. Adhesions between the mass and the pericardium and sternum were seen in the cranial thorax, and there were multiple nodules ranging in diameter from 0.5 to1.0 cm in the right pleural space. Several contact metastases, which were not connected directly to the ribs, were observed on the costal pleura. The ribs had no macroscopic lesions. Histological examination of the mass and neoplastic nodules revealed irregular osteoid islets, which were surrounded and occasionally infiltrated by malignant osteoblasts (Figure 4). The neoplastic osteoblasts were oval, elongated or spindle-shaped, and the nuclei were generally pleomorphic and often eccentrically placed. There were a few mitotic figures, and a large necrotic area was seen in the centre of the tumour. The definitive diagnosis was thoracic osteosarcoma with contact metastases on the costal pleura and diaphragm. In addition, there was severe acute pulmonary oedema with severe purulent pneumonia in the ventral lung lobes (presumably caused by aspiration) and mild verminous pneumonia in the diaphragmatic lung lobes.

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Extraskeletal osteosarcoma of the thorax in a goat: case report

Braun U, Schwarzwald CC, Forster E, Becker-Birck M, Borel N, Ohlerth S - BMC Vet. Res. (2011)

Gross pathological findings. Gross pathological findings in a miniature goat with thoracic osteosarcoma. 1 Precardial mass, 2 Lung, 3 Heart.
© Copyright Policy
Figure 3: Gross pathological findings. Gross pathological findings in a miniature goat with thoracic osteosarcoma. 1 Precardial mass, 2 Lung, 3 Heart.
Mentions: Because the prognosis was grave, the goat was euthanased and a post-mortem examination was carried out. Examination of the thorax revealed a large firm white oval mass cranial to the heart (Figure 3). The mass displaced the heart to the right side of the thorax and resulted in compression of the heart, trachea and lungs. The cut surface of the mass had cystic lesions and a central area of necrosis. Adhesions between the mass and the pericardium and sternum were seen in the cranial thorax, and there were multiple nodules ranging in diameter from 0.5 to1.0 cm in the right pleural space. Several contact metastases, which were not connected directly to the ribs, were observed on the costal pleura. The ribs had no macroscopic lesions. Histological examination of the mass and neoplastic nodules revealed irregular osteoid islets, which were surrounded and occasionally infiltrated by malignant osteoblasts (Figure 4). The neoplastic osteoblasts were oval, elongated or spindle-shaped, and the nuclei were generally pleomorphic and often eccentrically placed. There were a few mitotic figures, and a large necrotic area was seen in the centre of the tumour. The definitive diagnosis was thoracic osteosarcoma with contact metastases on the costal pleura and diaphragm. In addition, there was severe acute pulmonary oedema with severe purulent pneumonia in the ventral lung lobes (presumably caused by aspiration) and mild verminous pneumonia in the diaphragmatic lung lobes.

Bottom Line: Ultrasonographic examination of the thorax revealed a precardial mass, measuring 16.4 by 11.4 by 14.2 cm.Computed tomographic examination showed dorsocaudal displacement of the trachea, heart and lungs to the right.A definitive diagnosis was based on histological examination of the mass.

Affiliation: Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. ubraun@vetclinics.uzh.ch

ABSTRACT

Background:

Background: This report describes the results of clinical, ultrasonographic and computed tomographic examination of a 16-year-old goat with extraskeletal osteosarcoma of the thorax.

Case presentation: The lead clinical signs were abnormal condition and demeanour, fever, tachycardia, tachypnoea, dyspnoea and dilated jugular veins. Ultrasonographic examination of the thorax revealed a precardial mass, measuring 16.4 by 11.4 by 14.2 cm. Computed tomographic examination showed dorsocaudal displacement of the trachea, heart and lungs to the right. A tentative diagnosis of mediastinal or pleural neoplasia was made, and the goat was euthanased and necropsied. A definitive diagnosis was based on histological examination of the mass.

Conclusions: To our knowledge, this case report is the first description of extraskeletal osteosarcoma of the thorax in goats and serves to broaden the diagnostic spectrum of thoracic diseases in this species. Extraskeletal osteosarcoma should be part of the differential diagnosis in goats with thoracic tumours.

View Similar Images In: Results  - Collection
View Article: Pubmed Central - HTML -  PubMed
Show All Figures - Show MeSH
getmorefigures.php?pmc=3184056&rFormat=json&query=null&req=5