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Persistent alveolar soft-part sarcoma with liver metastasis: a case report

Silas OA, Adoga AA, Manasseh AN, Echejoh GO, Vhriterhire RA, Mandong BM - J Med Case Rep (2010)

Bottom Line: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality.A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf.Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

Affiliation: Department of Pathology, Jos University Teaching Hospital, PMB 2076, Jos, Plateau State, Nigeria. drgbenga@yahoo.com.

ABSTRACT

Introduction: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality. To the best of our knowledge, this is the first case describing metastasis to the liver reported from Nigeria.

Case presentation: A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf. It was initially diagnosed as soft-tissue sarcoma, and its associated systemic effects lead to his death before a histological diagnosis could be obtained.

Conclusions: Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

Stratified squamous epithelium overlying a fibrocollagenous stroma in which neoplastic cells arranged in alveolar pattern are evident.
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Figure 1: Stratified squamous epithelium overlying a fibrocollagenous stroma in which neoplastic cells arranged in alveolar pattern are evident.

Mentions: Microscopy showed oval to polygonal cells with eosinophilic cytoplasm delineated by thin fibrovascular septae which separated the tumor cells into an organoid or nest-like pattern of arrangement with evidence of vascular invasion (Figures 1 and 2). These features are consistent with that of alveolar soft-part sarcoma.

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Persistent alveolar soft-part sarcoma with liver metastasis: a case report

Silas OA, Adoga AA, Manasseh AN, Echejoh GO, Vhriterhire RA, Mandong BM - J Med Case Rep (2010)

Stratified squamous epithelium overlying a fibrocollagenous stroma in which neoplastic cells arranged in alveolar pattern are evident.
© Copyright Policy - open-access
Figure 1: Stratified squamous epithelium overlying a fibrocollagenous stroma in which neoplastic cells arranged in alveolar pattern are evident.
Mentions: Microscopy showed oval to polygonal cells with eosinophilic cytoplasm delineated by thin fibrovascular septae which separated the tumor cells into an organoid or nest-like pattern of arrangement with evidence of vascular invasion (Figures 1 and 2). These features are consistent with that of alveolar soft-part sarcoma.

Bottom Line: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality.A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf.Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

Affiliation: Department of Pathology, Jos University Teaching Hospital, PMB 2076, Jos, Plateau State, Nigeria. drgbenga@yahoo.com.

ABSTRACT

Introduction: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality. To the best of our knowledge, this is the first case describing metastasis to the liver reported from Nigeria.

Case presentation: A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf. It was initially diagnosed as soft-tissue sarcoma, and its associated systemic effects lead to his death before a histological diagnosis could be obtained.

Conclusions: Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

View Similar Images In: Results  - Collection
View Article: PubMed Central - HTML -  PubMed
Show All Figures - Show MeSH
getmorefigures.php?pmc=2922299&rFormat=json&query=null&req=5