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Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System

Zebib B, Mouloungui Z, Noirot V - Bioinorg Chem Appl (2010)

Bottom Line: The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent.Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively.On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

Affiliation: Université de Toulouse-UMR 1010, Laboratoire de Chimie Agro-Industrielle, ENSIACET, INPT, INRA, 4 allée Emile Monso, 31432 Toulouse Cedex 4, France.

ABSTRACT

The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

Normalized absorption spectrum of curcumin complexes compared with that of curcumin in DMSO solvent.
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fig3: Normalized absorption spectrum of curcumin complexes compared with that of curcumin in DMSO solvent.

Mentions: A UV-visible spectrum of the complexes in DMSO showed absorption maximum at 435 nm assigned to the band π → π* of curcumin (Figure 3). Compared with curcumin, the complexes in DMSO shows a maximum absorption shifted by (1–8 nm), which varies between (427–434 nm), and the shoulders at (410–413 nm) and (448–451 nm) are attributed to a curcumin → metal (M2+) charge transfer, specific complex formed. We believe that the variation of the absorption peak of curcumin and shoulders apparition in different complexes depend on the nature of metal (M2+) ion implication.

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Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System

Zebib B, Mouloungui Z, Noirot V - Bioinorg Chem Appl (2010)

Normalized absorption spectrum of curcumin complexes compared with that of curcumin in DMSO solvent.
© Copyright Policy - open-access
fig3: Normalized absorption spectrum of curcumin complexes compared with that of curcumin in DMSO solvent.
Mentions: A UV-visible spectrum of the complexes in DMSO showed absorption maximum at 435 nm assigned to the band π → π* of curcumin (Figure 3). Compared with curcumin, the complexes in DMSO shows a maximum absorption shifted by (1–8 nm), which varies between (427–434 nm), and the shoulders at (410–413 nm) and (448–451 nm) are attributed to a curcumin → metal (M2+) charge transfer, specific complex formed. We believe that the variation of the absorption peak of curcumin and shoulders apparition in different complexes depend on the nature of metal (M2+) ion implication.

Bottom Line: The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent.Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively.On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

Affiliation: Université de Toulouse-UMR 1010, Laboratoire de Chimie Agro-Industrielle, ENSIACET, INPT, INRA, 4 allée Emile Monso, 31432 Toulouse Cedex 4, France.

ABSTRACT

The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

View Similar Images In: Results  - Collection
View Article: PubMed Central -  PubMed
Show All Figures - Show MeSH
getmorefigures.php?pmc=2904446&rFormat=json&query=null&req=5