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Mycotic Giant Cell Epitheliomatous Inverted Papilloma of the Gingiva

Mohammed N, Kumar A, Vanessa T J, Syed S A - J Glob Infect Dis (2010)

Bottom Line: This report presents histopathological evidence of mycotic infection of the gingival epithelium followed by inverted verrucous giant cell epitheliomata of the gingiva.Sections from biopsy tissue revealed intercellular spaces of the parabasal squamous epithelium parasitized by Periodic Acid Schiff stain positive branching septate hyphae and conidia of morphological appearance of Trichophyton.Epithelial cells presented epitheliomatous proliferation with formation of giant cells showing phagocytosed fragments of mold.

Affiliation: Departments of Pathology JNMC, and Maxillofacial Surgery ZADC, AMU, Aligarh, UP, India.

ABSTRACT

This report presents histopathological evidence of mycotic infection of the gingival epithelium followed by inverted verrucous giant cell epitheliomata of the gingiva. Sections from biopsy tissue revealed intercellular spaces of the parabasal squamous epithelium parasitized by Periodic Acid Schiff stain positive branching septate hyphae and conidia of morphological appearance of Trichophyton. Epithelial cells presented epitheliomatous proliferation with formation of giant cells showing phagocytosed fragments of mold.

(A) PAS-positive hyphae parasitizing intercellular spaces between parabasal cells undergoing giant cell transformation (PAS, ×1,250), (B) phagocytosed fragments of septate fungal hyphae inside the parabasal epitheliomatous giant cell (PAS, ×1,250), and (C) conidia of trichophyton in the vicinity of epitheliomatous giant cells (PAS, ×1,250)
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Figure 0002: (A) PAS-positive hyphae parasitizing intercellular spaces between parabasal cells undergoing giant cell transformation (PAS, ×1,250), (B) phagocytosed fragments of septate fungal hyphae inside the parabasal epitheliomatous giant cell (PAS, ×1,250), and (C) conidia of trichophyton in the vicinity of epitheliomatous giant cells (PAS, ×1,250)

Mentions: Periodic Acid Schiff (PAS) stained sections revealed septate branching fungal hyphae of mold parasitizing intercellular clefts in basal and parabasal squamous layers, with the cells around undergoing immunoactive and giant cell transformations [Figure 2A]. Some of the giant cells showed phagocytosed hyphae [Figure 2B]. Rarely, conidia characteristic of tricophyton were observed in close vicinity or within the giant cells [Figure 2C]. Above the parabasal layers, PAS-positive dust was seen in the keratinocytes, but no fragments of mold could be identified.

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Mycotic Giant Cell Epitheliomatous Inverted Papilloma of the Gingiva

Mohammed N, Kumar A, Vanessa T J, Syed S A - J Glob Infect Dis (2010)

(A) PAS-positive hyphae parasitizing intercellular spaces between parabasal cells undergoing giant cell transformation (PAS, ×1,250), (B) phagocytosed fragments of septate fungal hyphae inside the parabasal epitheliomatous giant cell (PAS, ×1,250), and (C) conidia of trichophyton in the vicinity of epitheliomatous giant cells (PAS, ×1,250)
© Copyright Policy - open-access
Figure 0002: (A) PAS-positive hyphae parasitizing intercellular spaces between parabasal cells undergoing giant cell transformation (PAS, ×1,250), (B) phagocytosed fragments of septate fungal hyphae inside the parabasal epitheliomatous giant cell (PAS, ×1,250), and (C) conidia of trichophyton in the vicinity of epitheliomatous giant cells (PAS, ×1,250)
Mentions: Periodic Acid Schiff (PAS) stained sections revealed septate branching fungal hyphae of mold parasitizing intercellular clefts in basal and parabasal squamous layers, with the cells around undergoing immunoactive and giant cell transformations [Figure 2A]. Some of the giant cells showed phagocytosed hyphae [Figure 2B]. Rarely, conidia characteristic of tricophyton were observed in close vicinity or within the giant cells [Figure 2C]. Above the parabasal layers, PAS-positive dust was seen in the keratinocytes, but no fragments of mold could be identified.

Bottom Line: This report presents histopathological evidence of mycotic infection of the gingival epithelium followed by inverted verrucous giant cell epitheliomata of the gingiva.Sections from biopsy tissue revealed intercellular spaces of the parabasal squamous epithelium parasitized by Periodic Acid Schiff stain positive branching septate hyphae and conidia of morphological appearance of Trichophyton.Epithelial cells presented epitheliomatous proliferation with formation of giant cells showing phagocytosed fragments of mold.

Affiliation: Departments of Pathology JNMC, and Maxillofacial Surgery ZADC, AMU, Aligarh, UP, India.

ABSTRACT

This report presents histopathological evidence of mycotic infection of the gingival epithelium followed by inverted verrucous giant cell epitheliomata of the gingiva. Sections from biopsy tissue revealed intercellular spaces of the parabasal squamous epithelium parasitized by Periodic Acid Schiff stain positive branching septate hyphae and conidia of morphological appearance of Trichophyton. Epithelial cells presented epitheliomatous proliferation with formation of giant cells showing phagocytosed fragments of mold.

View Similar Images In: Results  - Collection
View Article: PubMed Central -  PubMed
Show All Figures - Show MeSH
getmorefigures.php?pmc=2889661&rFormat=json&query=null&req=5