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Hsp70 enhances presentation of FMDV antigen to bovine CD4+ T cells in vitro
Bottom Line: Hsp70 was found to consistently improve the presentation of a 25-mer FMDV peptide to CD4+ T cells, as measured by T cell proliferation.Complex formation was required for the enhanced effects and Hsp70 alone did not stimulate proliferation.This study provides further evidence that Hsp70:peptide complexes can enhance antigen-specific CD4+ T cell responses in vitro for an important pathogen of livestock.
Affiliation: Institute for Animal Health, Pirbright, Woking, Surrey GU24 0NF, United Kingdom.
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